Utilization of scoring system in diagnosis of Chronic Lymphocytic Leukemia in Indian population.

Dr. Ekta Dwivedi; Dr. Suman kumari Pandey; Dr. U.S. Singh

Volume : VII, Issue : IX, September - 2018

Utilization of scoring system in diagnosis of Chronic Lymphocytic Leukemia in Indian population.

Dr. Ekta Dwivedi, Dr. Suman Kumari Pandey, Dr. U. S. Singh

Abstract :

Introduction

CLL is a rare B–lymphoid malignancy in Asian population and very few studies available in indian population . Here we have done prospective study evaluating a scoring system based on the expression of CD5 , CD23, FMC7,CD22 and surface immunoglobulin to distinguish CLL from other types of lymphoid neoplasms in the Indians.

Material and methods:

48 patients samples with a clinical as well as morphological features of chronic lymphoproliferative disorders were analysed by flow cytometry. A score of one was given if the following markers were assigned CD5+, CD23+,FMC7–,CD22+ and surface immunoglobulins.

Results:

Only 26 cases were confirmed as B–CLL(score > 3). In 22 cases with scores < or =3, a variety of non–CLL disorders predominated, such as lymphoplasmacytic lymphoma , hairy cell leukemia, mantle cell lymphoma, and prolymphocytic leukemia.

CONCLUSION:

A score of 4 and dual CD5/CD23 expression are essential for the diagnosis of CLL while a score of 2 mostly indicative of non–CLL. Scoring system using CD5, CD23, CD22, FMC7, and SmIg was found to be useful in differentiating CLL from other CLPDs. CD5, CD23, and FMC7 were identified as most sensitive markers in differentiating CLL from other CLPDs.