Volume : VII, Issue : VII, July - 2018

Zidovudine and Efavirenz induced fetal toxicity in swiss albino mice

Dr Anand Mishra, Dr Rakesh Gupta, Dr Amit Kumar Nayak, Dr Kapil Kumar Malviya, Dr Sashikant Pandey, Dr Surendra Kumar Pandey, Dr Sashikant Verma

Abstract :

 Introduction: Zidovudine and Efavirenz are anti HIV drugs which are used in pregnancy to prevent maternal to child transmission.

Material and Methods: Zidovudine and Efavirenz are given separately as well as together in dose of 50mg/kg to pregnant mice
and its effect on fetal toxicity was recorded by measuring number of implants , live fetuses , resorption in a single mice. Weight of
the fetus as well as its crown rump length was also recorded.
Observation: There is decrease in number of implants, live fetus and increase in resorption from group I to IV. Also there is
decrease in fetal weight and crown rump length from group I to IV.
Conclusion: There is fetal toxicity induced by Zidovudine and Efavirenz and thus should be used with caution in 1st trimester of
pregnancy

Keywords :

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

Dr Anand Mishra, Dr Rakesh Gupta, Dr Amit Kumar Nayak, Dr Kapil Kumar Malviya, Dr Sashikant Pandey, Dr Surendra Kumar Pandey, Dr Sashikant Verma, Zidovudine and Efavirenz induced fetal toxicity in swiss albino mice, PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-7 | Issue-7 | July-2018


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