2,4–Dinitrophenol Toxicity–Bound Mortality in Patients Doing Bodybuilding

Meltem Turkay; Abdulhalim Karayel; Emin Uysal; Mehmet Salih Sevdi; Kerem Erkalp; Aysin Alagol

Volume : III, Issue : IX, September - 2014

2,4–Dinitrophenol Toxicity–Bound Mortality in Patients Doing Bodybuilding

Meltem Turkay, Abdulhalim Karayel, Emin Uysal, Mehmet Salih Sevdi, Kerem Erkalp, Aysin Alagol

Abstract :

2,4–Dinitrophenol (DNP) intoxication is a condition that may result in mortality together with uncontrolled hypothermia and epidemic muscle rigidity. In excessive doses, hyperthermia, tachycardia, excessive sweating, tachypnea, acute renal damage, confusion, agitation, convulsion, and coma may be observed. DNP therapeutic index is a narrow agent. In acute and suicidal exposure, the oral lethal dose changes between 2,8 and 5 gr, and the average has been reported as 4,3 mg/kg. The dose taken orally by our patient who is known to be a sportsman doing body–building exercises is below the lethal dose of 1,8 gr. It must be taken into consideration that a patient can be lost even if the dose is below the lethal dose and adequate support treatment is applied.