A clinical evaluation of serum ferritin, gamma–glutamyltransferase (GGT) and vitamin D with alcoholic liver diseases for diagnosis

Sunil Jain; R.K.Vyas; Yogita Soni; Ghanshyam Gahlot

Volume : VIII, Issue : V, May - 2019

A clinical evaluation of serum ferritin, gamma–glutamyltransferase (GGT) and vitamin D with alcoholic liver diseases for diagnosis

Sunil Jain, R. K. Vyas, Yogita Soni, Ghanshyam Gahlot

Abstract :

Background: Alcohol is most common substance abused. Alcoholic liver disease is a major health care problem in India. Alcohol consumption is directly associated with liver disease mortality and accounts for increased social and economic costs. Alcoholic liver disease may take the forms of acute involvement (alcoholic hepatitis) or chronic liver disease (steatosis, steatohepatitis, fiosis and cirrhosis. The severity and prognosis of alcohol– induced liver disease depends on the amount, pattern and duration of alcohol consumption, as well as on the presence of liver inflammation, diet, nutritional status and genetic predisposition of an individual. Aims & objective: The aim of the current study was to analyze the correlation of gamma–glutamyltransferase (GGT); vitamin D; and ferritin with alcoholic liver disease and clinical presentation to access the severity of alcoholic liver disease and their treatment response and outcome among patients using laboratory. Material and Methods: It is observational case control study, was included 100 subjects. Out of 100 subjects, 50 subjects were patients of alcoholic liver disease and another 50 normal subjects, were age and sex matched healthy volunteers as control group. 50 ALD patients were studied and their clinical profile, laboratory parameters and radiological investigations were taken. Results: Alcoholic liver disease was seen among the productive age group with high morbidity and mortality. The statistically inverse significant correlations were recorded between serum vit.D and ferritin. While, serum Vit.D and GGT besides that highly statistically significant inverse correlation and ferritin with GGT positive significant correlations were found in alcohol liver disease subjects. Conclusion: Alcoholic liver disease was seen among the productive age group with high morbidity and mortality. Mortality and morbidity associated with this disease is matter of serious economic loss to the nation and grief for the society.