Volume : VI, Issue : II, February - 2017
A CLINICAL STUDY OF THYROID MALIGNANCY AND ROLE OF TSH IN PREDICTING MALIGNANCY
Dr. F. Celine Foustina Mary, Dr. K. Ashok Kumar, Dr. Shiva Kumar Rathlawath
Abstract :
BACKGROUND
Many patients present to the surgical department with a thyroid nodule.
However not all require surgery and only 5–6% of these are malignant. There
are many methods to diagnose and predict malignancy in a thyroid nodule. This
study throws light on the usefulness of TSH estimation and its role in predicting
malignancy.
AIMS AND OBJECTIVES
1) To evaluate the utility of serum TSH estimation as a biochemical
predictor of malignancy in suspicious thyroid nodules.
2) To study the clinical presentation and management of various thyroid
malignancies.
MATERIAL AND METHODS:
This prospective study involved 50 patients admitted to Madurai medical
college, madurai with thyroid swellings suspicious of malignancy. A descriptive
analysis of clinical presentation and a correlation of TSH level and final
histopathology were done.
OBSERVATION AND RESULTS
Most patients were females. The Mean age of malignancy was 40 years
with a higher mean age in males (59 years) as compared to females (38 years).
Commonest presentation was a rapidly growing thyroid swelling of short
duration or development of secondary symptoms in a long standing goitre.
Majority of patients presented with a SNT. The incidence of malignancy was
higher in SNT (36%) compared to MNG (19%). 4 patients presented with
primary complaints other than a neck swelling. patients presented with cystic
swelling of neck which turned out to be cervical lymph node metastasis. The
incidence of neck nodes was 20% and distant metastasis was 0%. .Mean
preoperative TSH value in malignancy was higher compared to those with
benign disease. Incidence of malignancy increased with higher TSH values.
CONCLUSION
There is a definite relationship between higher TSH levels and
malignancy. TSH levels could be used as predictor in clinically suspect
malignant thyroid swelling with a benign FNAC report. In such cases where
TSH value is high, the FNAC can be relooked to confirm the diagnosis.
Keywords :
Article:
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DOI : 10.36106/ijsr
Cite This Article:
Dr.F.Celine Foustina Mary, Dr.K.Ashok Kumar, Dr. Shiva Kumar Rathlawath, A CLINICAL STUDY OF THYROID MALIGNANCY AND ROLE OF TSH IN PREDICTING MALIGNANCY, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : VOLUME-6 | ISSUE-2 | FEBRUARY-2017
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References :
Dr.F.Celine Foustina Mary, Dr.K.Ashok Kumar, Dr. Shiva Kumar Rathlawath, A CLINICAL STUDY OF THYROID MALIGNANCY AND ROLE OF TSH IN PREDICTING MALIGNANCY, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : VOLUME-6 | ISSUE-2 | FEBRUARY-2017
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