A Comparative Evaluation of Efficacy of Epidural Dexmedetomidine and Fentanyl as Adjunct to 0.2% Ropivacaine for Post Operative Analgesia in Elective Abdominal Surgeries.

Anuja Bhushan Dua; Sadhana Sanwatsarkar

Volume : VII, Issue : VI, June - 2018

A Comparative Evaluation of Efficacy of Epidural Dexmedetomidine and Fentanyl as Adjunct to 0.2% Ropivacaine for Post Operative Analgesia in Elective Abdominal Surgeries.

Anuja Bhushan Dua, Sadhana Sanwatsarkar

Abstract :

This clinical study is undertaken to compare the efficacy of epidural dexmedetomidine and fentanyl in addition to 0.2% ropivacaine for post–operative analgesia in elective abdominal surgeries in ASA grade I and II patients with regardsto comp� the onset, duration , hemodynamics, sedation, rescue analgesic requirement and safety profile. Inclusion criteria was patients between 18–55 years undergoing elective abdominal surgeries. The patients were randomly allocated into three groups of 25 patients each. Group R received Ropivacaine 0.2% 9ml with 1ml Normal Saline. Group RF received Ropivacaine 0.2% 9ml with fentanyl 50� (1ml) Group RD received Ropivacaine 0.2% 9ml with dexmedetomidine 1�/kg .The set parameters were studied. The groups were similar in age, sex, weight and ASA grading and haemodynamic parameters after administering the drug. The mean duration of analgesia in group RD was significantly longer than in group RF which was significantly longer than in group R. Duration of sedation correlated with the duration of analgesia in all the groups, being the highest in group RD and did not result in respiratory depression at any time in the study period. Incidence of side effects comparable in all groups.The addition of dexemedetomidine to ropivacaine when compared with addition of fentanyl resulted in earlier onset and prolonged duration of analgesia in intra abdominal surgeries with less requirement of rescue analgesics after administering the drug through epidural route with minimal side effects in the patients.