A Comparative Study between Intravenous Sodium Valproate And Phenytoin Sodium As Second-Line Treatment of Status Epilepticus In Children

Dr. Amit Das; Dr. Archan Sil; Dr. Sourav Roy Choudhury; Dr. Tanmoy Biswas

Volume : VII, Issue : IV, April - 2018

A Comparative Study between Intravenous Sodium Valproate And Phenytoin Sodium As Second-Line Treatment of Status Epilepticus In Children

Dr. Amit Das, Dr. Archan Sil, Dr. Sourav Roy Choudhury, Dr. Tanmoy Biswas

Abstract :

Objectives– To demonstrate the efficacy of intravenous (IV) valproate as the second–line therapy for controlling seizures in patients of Status Epilepticus (SE) and to compare it with IV phenytoin.Material And Methods– Children aged 2 yrs–12 yrs, admitted in Pediatric emergency ward and PICU with status epilepticus were included in the study. This was a hospital based randomized control clinical study. Results– Total 60 children aged 2–12 yr were included in the study. In the group that received IV valproate, 100% seizure was controlled in children presented within 2 hrs, whereas in the group that received IV phenytoin 70.83% of patients presenting within 2 hrs had seizure controlled. (p value 0.008) Conclusion– Sodium valproate was found better in comparison to phenytoin in controlling SE with seizure duration <2hrs and in reducing recurrence of seizure within 12 hours.