A comparative study between two dose fractionation schedules; 8 Gy in single fraction versus 30 Gy in 10 fractions in palliative management of bone metastases.

Dr Jyotiman Nath; Dr Gautam Sarma

Volume : VII, Issue : VI, June - 2018

A comparative study between two dose fractionation schedules; 8 Gy in single fraction versus 30 Gy in 10 fractions in palliative management of bone metastases.

Dr Jyotiman Nath, Dr Gautam Sarma

Abstract :

Bone is the third most common site affected by metastatic disease, after the lung and the liver. Since pain is the major cause of morbidity in these patients, pain control significantly improves quality of life. The aim of the study is to compare the single fraction radiotherapy (8Gy) with multiple fraction radiotherapy (30Gy in 10 fractions) in management of painful bone metastases in terms of pain palliation and analgesic requirement. This is a hospital based prospective study where 44 patients of painful bone metastases were enrolled. Arm A (n=21) and Arm B (n=23) received 8 Gy in single fraction and 30 Gy/10 fractions respectively. Pain palliation was compared between the groups and there was no significant difference in pain palliation at the end of 3 months (p=0.66). Regarding analgesic requirement at 3 months by the two groups, both the fraction schedules are statistically similar (p=0.67)