A COMPARATIVE STUDY OF ANALGESIC EFFECT OF INTRATHECAL NEOSTIGMINE, FENTANYL AND COMBINATION OF BOTH AS AN ADJUVANT TO INTRATHECAL BUPIVACAINE and BUPIVACAINE ALONE FOR ABDOMINAL HYSTRECTOMY.

Dr. Jigyasa Shahani; Dr. Fareed Ahmed

Volume : VIII, Issue : II, February - 2019

A COMPARATIVE STUDY OF ANALGESIC EFFECT OF INTRATHECAL NEOSTIGMINE, FENTANYL AND COMBINATION OF BOTH AS AN ADJUVANT TO INTRATHECAL BUPIVACAINE and BUPIVACAINE ALONE FOR ABDOMINAL HYSTRECTOMY.

Dr. Jigyasa Shahani, Dr. Fareed Ahmed

Abstract :

Many options are available for post–operative analgesia including systemic analgesics and regional techniques. The aim of this study was to compare analgesic duration of combination of fentanyl and neostigmine with intrathecal bupivacaine, fentanyl and neostgmine alone with intrathecal bupivacaine.Method: 164 patients of ASA grade I and II, scheduled for elective Total Abdominal Hysterectomy under subarachnoid block were randomly allocated to four groups (n=41): Group A received 15mg bupivacaine intrathecally.Group B received 15mg bupivacaine plus 25 micrograms of fentanyl intrathecally.Group C received 15mg bupivacaine plus 25 micrograms neostigmine intrathecally.Group D received 15mg bupivacaine plus 25 micrograms neostigmine and 25 micrograms fentanyl intrathecally with total volume made upto 4.0ml with NS in each group.Result: Duration of analgesia in post operative period was group A (126.05�19.33 minutes),group B (208.2�15.74 minutes),group C (194.37�15.54 minutes),group D (290.8�20.24 minutes. Conclusion: The combination of intrathecal neostigmine and fentanyl with bupivacaine significantly prolonged post operative analgesia as compared to other three study groups.