A COMPARATIVE STUDY OF CENTCHROMAN VS TAMOXIFEN IN THE MANAGEMENT OF MASTALGIA AND FIBROADENOMA

Debasis Dhar; Dr.Sumikesh Anand; Dr.Debasis Sarkar; Prof Saibal Kumar Mukherjee; Prof. Sushil Kumar Paira; Ramanuj Mukherjee

Volume : VII, Issue : III, March - 2018

A COMPARATIVE STUDY OF CENTCHROMAN VS TAMOXIFEN IN THE MANAGEMENT OF MASTALGIA AND FIBROADENOMA

Debasis Dhar, Dr. Sumikesh Anand, Dr. Debasis Sarkar, Prof Saibal Kumar Mukherjee, Prof. Sushil Kumar Paira, Ramanuj Mukherjee

Abstract :

We conducted an interventional, experimental, randomized, prospective study to compare the efficacy of a newer therapeutic agent Centchroman with established therapeutic agents Tamoxifen in the treatment of mastalgia and fioadenoma. Total 84 patients have been participated in the study (only mastalgia–36, mastalgia with fioadenoma–48). In mastalgia group 19 and 17 patients were treated with Centchroman and Tamoxifen respectively. In fioadenoma group 26 and 22 patients received Centchroman and Tamoxifen respectively. Centchroman was found to be the most effective drug with the post intervention pain scores =<2 in 30 (66.67%) patients and 17 (43.59%) with Tamoxifen. In fioadenoma group complete response rate was highest in Centchroman arm 12(26.67%) in comparison to 2(5.13%). Side effects are maximum with Tamoxifen and Centchroman is the cheapest.