A COMPARATIVE STUDY OF CONVENTONAL TECHNIQUES AND HAND HELD PROBE BASED ON ON POLARIZED FLOURESCENCE SPECTROSCOPY IN DETECTION OF CERVICAL PRECANCEROUS AND CANCEROUS LESIONS

Guneeta Mehta; Kiran Pandey; Asima Pradhan; Amarveer Singh Mehta; Ajay Bhagoliwal; Bharat Lal Meena; Asha Agarwal

Volume : V, Issue : XI, November - 2016

A COMPARATIVE STUDY OF CONVENTONAL TECHNIQUES AND HAND HELD PROBE BASED ON ON POLARIZED FLOURESCENCE SPECTROSCOPY IN DETECTION OF CERVICAL PRECANCEROUS AND CANCEROUS LESIONS

Guneeta Mehta, Kiran Pandey, Asima Pradhan, Amarveer Singh Mehta, Ajay Bhagoliwal, Bharat Lal Meena, Asha Agarwal

Abstract :

OBJECTIVES: To diagnose early cervical neoplasia by cytology, colposcopy, histopathology and polarized fluorescence spectroscopy with aid of handheld probe and to compare the efficacy of these modalities in detection of early cervical neoplasm. METHODS: ?e study was conducted in 81 patients undergoing hysterectomy in UISEMH, LLR Hospital between December 2013 to October 2015. All patients were subjected to cytology and colposcopy. Each of the hysterectomized sample was evaluated by a team from IIT Kanpur with hand held probe, based on polarised fluorescence. ?e sample was then sent to Pathology dept of GSVM Medical College for histopathology. ?e findings were then collaborated, considering histopathology as the gold standard. RESULTS: ?e sensitivity of hand held probe in detecting precancerous lesions using co–polarized light was 92.86% while specificity was 94.87%, while for cross polarized light, sensitivity was 92.86% and specificity was 89.74%. CONCLUSION: ?e hand held probe based on optical spectroscopy is an excellent screening modality that helps to detect precancerous lesions of the cervix. It has the added advantage that it is minimally invasive, can be used in rural set up by paramedics after little training