Volume : VIII, Issue : VII, July - 2019

A comparative study of dexmedetomidine and esmolol for attenuation of hemodynamic stress response to laryngoscopy and intubation

Dr. A. Abdul Hakkim, Dr. Sasikumar P

Abstract :

Study objective: During General Anesthesia, laryngoscopy and intubation is a noxious stimuli that lead to profound hemodynamic changes during GA. Various drugs and maneuvers helps to decrease the stress responses related to laryngoscopy. In our study we compare the clinical effects of dexmeditomidine with esmolol in attenuating the stress response during laryngoscopy and intubation. Study place: Study was conducted at Department of Anesthesiology, TRICHY SRM Medical College Hospital & Research centre,Trichy Design: A randomized, prospective, double–blind, controlled study Subjects & methods: We studied 90 adults belonging to ASA–PS I & II patients of either sex, scheduled for non–cardiac surgery requiring intubation and general anesthesia. The patients were randomly divided into three groups (no–30). Group P receiving placebo (20 ml of normal saline), Group E received 1.5ml/kg of esmolol and Group D received 1mcg/kg of dexmeditomidine 1 minute before induction of general anesthesia. All patients were uniformly pre medicated, induced and intubated. Measurements & analysis: Base line parameters like Heart Rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and Mean blood pressure(MAP) and oxygen saturation were recorded on arrival at operating room, then at various intervals – 1minute after the study drug, after induction of anesthesia and 1minute, 3minutes 5 minutes, 7minutes and 10 minutes after intubation. We used chi–square test, ANOVA tests as appropriate after entering data. Results: There is statistically significant difference between the groups in the mean heart rate after injection. The mean heart rate in group D is lower than that of group E & P. the heart rate, MAP, SBP & DBP increase to laryngoscopy and intubation was effectively suppressed in group D compared to group E. In group D, the pressures after intubation at 1 minute, 3 minutes, 5 minutes, 7 minutes and 10 minutes were less than group E. Conclusion: Both the dugs attenuated the pressure response. Of the two drugs administered, dexmeditomidine 1.0 mcg/kg provides a consistent, reliable and effective attenuation of pressure response when compared to esmolol 1.5 mg/kg.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND ESMOLOL FOR ATTENUATION OF HEMODYNAMIC STRESS RESPONSE TO LARYNGOSCOPY AND INTUBATION, Dr.A.Abdul Hakkim, Dr.Sasikumar P INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-7 | July-2019

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