A Comparative Study of efficacy of Rosuvastatin and Atorvastatin in Combination with Fenofibrate in Dyslipidemia

Dr.M.Damodari Bai

Volume : V, Issue : X, October - 2016

A Comparative Study of efficacy of Rosuvastatin and Atorvastatin in Combination with Fenofibrate in Dyslipidemia

Dr. M. Damodari Bai

Abstract :

Aim: The main of the study is to compare the effects of Atorvastatin and Rosuvastatin in combination with fenofiate in patients with Dyslipidemia. Materials and Methods: It was randomized, parallel group, comparative, prospective clinical study conducted in ACSR. Government Medical College, Nellore. A total of 60 subjects diagnosed with dyslipidemia were screened and were randomly allocated into two groups of thirty each. Initial readings of lipid levels like TC, TG, HDL, LDL and VLDL for both the groups were taken as baseline values. Then, Group I received Tab Atorvastatin 10 mg + Fenofiate 160 mg and Group II received Tab Rosuvastatin 10 mg+ Fenofiate 160 mg once a day at night for 12 weeks. Patients were assessed after 12 weeks and their Lipid profile was done. Results: Patients who received a combination of atorvastatin with fenofiate had a reduction of Total cholesterol by 39%, Triglycerides by 47%, LDL–C by 50% and VLDL–C by 35% respectively. In group treated with combination of rosuvastatin with fenofiate there was a decrease in TC by 54%, TGs by 58%, LDL–C by 52% and VLDL–C by 56% respectively. At the same time, HDL–C levels were increased by 14% in the group treated with rosuvastatin with fenofiate as compared to atorvastatin with fenofiate treated group which increased the HDL–C levels by 6%. Conclusion: Both the treatment regimens significantly decreased TC, TG, LDL?C, VLDL?C, but the reduction was more and statistically significant in Rosuvastatin and fenofiate combination group when compared with atorvastatin and fenofiate treated group at the end of 12 weeks.