A Comparative study of Intrathecal Nalbuphine Hydrochloride with Hyperbaric Bupivacaine 0.5% and Hyperbaric Bupivacaine 0.5% Alone in Patients undergoing Lower Abdominal Surgery

Dr. Sanjay Kumar Mahto; Dr. Rajesh Khanna; Dr. Praveen Kumar Tiwari; Dr. Usha Suwalka

Volume : VII, Issue : IV, April - 2018

A Comparative study of Intrathecal Nalbuphine Hydrochloride with Hyperbaric Bupivacaine 0.5% and Hyperbaric Bupivacaine 0.5% Alone in Patients undergoing Lower Abdominal Surgery

Dr. Sanjay Kumar Mahto, Dr. Rajesh Khanna, Dr. Praveen Kumar Tiwari, Dr. Usha Suwalka

Abstract :

Introduction:Spinal anesthesia is the most commonly used regional anesthesia technique today. It offers several advantages over general anesthesia. Intrathecal opioids are synergistic with local anesthetics and intensify the sensory block without increasing the sympathetic block. They are commonly added to local anesthetics for potentiating their effects, reducing their doses, and thereby reducing their complications and side effects and offer hemodynamic stability. Nalbuphine is a mixed agonist–antagonist opioid.It has a potential to attenuate the mu opioid effects and to enhance the kappa opioid effects. Materials and Method:Randomized double blind study done on 120 patients undergoing lower abdominal surgeries under subarachnoid block. Patients were randomly allocated to two groups receiving either 17.5 mg of bupivacaine with 0.4ml of nalbuphine(0.8mg) in Group Nor intrathecal 17.5 mg of bupivacaine +0.4 mL normal saline alone IN Group B.Result:the onset of sensory and motor blockade, highest level of sensory blockade, duration of motor blockade and analgesia, VAS score, hemodynamic and respiratory changes,side effects were recorded, tabulated, and analyzed. Onset of sensory and motor blockade was faster in group N. The VAS scores showed that post–operative analgesia lasted significantly in patients in group N than in group B. No significant side effects were observed in either of the two groups.Conclusion: Thus we conclude that intrathecal nalbuphine improved the quality of intraoperative and postoperative analgesia, with minimal side effects.