IJSR - International Journal of Scientific Research

Dr. Braj Nandan Kumar Sah; Dr. Sara Sultana

Volume : VIII, Issue : VIII, August - 2019

A comparative Study of Metformin on Thyroid Stimulating Hormones in Patients with Euthyroid Type 2 Diabetes Mellitus.

Dr. Braj Nandan Kumar Sah, Dr. Sara Sultana

Abstract :

Objectives: This present study was to compare the effect of metformin on thyroid stimulating hormones of euthyroid type 2 diabetes mellitus patients. Methods: A detail history, clinical examinations and relevant investigations were performed to all cases of euthyroid type 2 diabetes mellitus. Collected blood sample was centrifuged and serum obtained was used for estimation of glucose and thyroid levels. Glucose was estimated by glucose oxidase peroxidase test. T3, T4 and TSH levels were estimated by immunoassay. Glycosylated hemoglobin (HbA1c) was determined by ion–exchange chromatography. Results: Data was analysed with the help of SPSS (Version 26) software. Paired sample statistics was used. Mean ± Standard deviation were observed. P value was taken less than or equal to 0.05 (pâ‰¤0.05) for significant differences. Conclusions: This present study concluded that the metformin was not significantly affected the levels of serum thyroid stimulating hormones in euthyroid type 2 diabetes mellitus patients. Hence, in the primary prevention of diabetes, use of metformin is proven to be effective and safe