A comparative Study on Serum Leptin and Adiponectin levels in Periodontitis Patients with and without Diabetes Mellitus Type2

Vean S. AL-Azawy; Dr. Abdulwahid Sh. JABIR; Dr. Batool H. Al-Ghurabi

Volume : III, Issue : V, May - 2014

A comparative Study on Serum Leptin and Adiponectin levels in Periodontitis Patients with and without Diabetes Mellitus Type2

Vean S. Al Azawy, Dr. Abdulwahid Sh. Jabir, Dr. Batool H. Al Ghurabi

Abstract :

Background: Periodontal diseases are initiated by microbial plaque, which accumulates in the sulcular region and induces an inflammatory response. Recently studies found that periodontitis might be related to several systemic diseases especially diabetes mellitus. In recent years, there has been intense interest in the role of the adipose tissue derived substances that named adipokines in the inflammatory diseases of the human being including the inflammatory periodontitis. Aims of study: This study was performed to evaluate the serum level of leptin and adiponectin in periodontitis with and without type 2 diabetes mellitus (T2DM), to determine the association between serum level of the biochemical markers (leptin and adiponectin) with clinical periodontal parameter and determine the correlation between adiponectin and leptin levels. Material and Methods: Sixty patients (30 periodontitis patients and 30 periodontitis+T2DM patients) and 25 apparently healthy volunteers were enrolled in this study. Periodontal parameters used in this study were plaque index, gingival index, probing pocket depth, clinical attachment level and bleeding on probing. Serum levels of leptin and adiponectin were estimate by ELISA. Results: The present data revealed a significant elevation (p0.05). On the other hand, there is significant decrease (p