A Comparative Study to Evaluate the Efficacy of  Oral Fexofenadine Hydrochloride and Topical  Mometasone Furoate in Decreasing Symptoms of  Moderate–Severe Allergic Rhinitis.

Dr. Smitha.S.G; Dr.Jagannath.B

Volume : II, Issue : VI, June - 2013

A Comparative Study to Evaluate the Efficacy of Oral Fexofenadine Hydrochloride and Topical Mometasone Furoate in Decreasing Symptoms of Moderate–Severe Allergic Rhinitis.

Dr. Smitha. S. G, Dr. Jagannath. B

Abstract :

Objectives-Allergic rhinitis is a common and debilitating disease that has major effect on health related quality of life. For several years, there has been discussions of whether first line pharmacological treatment of moderate-severe allergic rhinitis should be antihistamines or intranasal corticosteroids. Hence, this study was done to clinically evaluate the efficacy of fexofenadine hydrochloride and topical mometasone furoate in treatment of moderate-severe allergic rhinitis. Methods- 100 patients aged between 12-65 years with moderate-severe allergic rhinitis who fulfilled the inclusion criteria were sequentially randomized into two groups and treated with either topical mometasone furoate spray or fexofenadine hydrochloride for 4 weeks. Patients were given a symptom diary to record the efficacy of their treatment on daily basis. Results- Significant reduction in severity of individual symptoms in mometasone group compared to fexofenadine group was noted(p<0.01). Symptoms score decreased from baseline mean by 99-100% in mometasone group compared to 90-91% in fexofenadine group. Fexofenadine hydrochloride had rapid onset of action compared to mometasone furoate. Conclusion- Mometasone furoate is superior in relieving symptoms compared to fexofenadine hydrochloride.