A Comparison of the Efficacy and Tolerability of Antibiotics in the Treatment of Acute Rhinosinusitis in Adults

Dr.Anil.H.T; Dr.Amrita Suzanne Mathew

Volume : III, Issue : X, October - 2014

A Comparison of the Efficacy and Tolerability of Antibiotics in the Treatment of Acute Rhinosinusitis in Adults

Dr. Anil. H. T, Dr. Amrita Suzanne Mathew

Abstract :

Objectives–to compare the efficacy and tolerability of amoxicillin–clavulanate, cefuroxime axetil and moxifloxacin in the treatment of acute bacterial rhinosinusitis in adults. Methods–90 adults aged 18–40years, clinically diagnosed with acute rhinosinusitis,symptomatic for 7–28days, were randomised into three groups,each receiving an oral antibiotic ie.Amoxicillin–clavulanate(GroupA),Cefuroxime (GroupB),Moxifloxacin(GroupC) and evaluated on days 0,7,14,21,28,60 using Major Symptom Score,Visual Analogue Scale for quality of life and Axelsson�s sinus X–ray score.Time to improvement, relapse,recurrence and adverse events were noted. Result–In Group A,B,C clinical cure rate was 89.86%, 92.76%, 96.57% respectively; mean time to improvement was 4.36, 4.07, 3.39 days respectively. Relapse,recurrence and adverse events(diarrhoea, nausea and rash) were highest with amoxicillin–clavulanate. Conclusion– Moxifloxacin shows highest efficacy and tolerability.Cefuroxime and amoxicillin–clavulanate have similar clinical cure rates. Cefuroxime has lower relapse,recurrence and adverse event rates.