A Prospective Cohort Study Comparing Three Dimensional Image Guided Intracavitary Brachytherapy and Conventional Brachytherapy for Dosimetry in Carcinoma Cervix

Rohith Singareddy; Harjot Kaur Bajwa; T.Anil Kumar

Volume : V, Issue : V, May - 2016

A Prospective Cohort Study Comparing Three Dimensional Image Guided Intracavitary Brachytherapy and Conventional Brachytherapy for Dosimetry in Carcinoma Cervix

Rohith Singareddy, Harjot Kaur Bajwa, T. Anil Kumar

Abstract :

PURPOSE:A dosimetric comparison between the standard point A intracavitary achytherapy technique and Image Guided Brachytherapy (IGBT) technique, to assess the feasibility of IGBT in the Indian scenario METHODS: Between August 2013 and June 2015, 30 patients of carcinoma cervix were enrolled in the study. Two plans were created for each patient, the conventional plan prescribing dose to point A and CT scan based IGBT plan, prescribing dose to High Risk Clinical Target Volume(HRCTV) RESULTS:On analysis, there was a significant difference in terms of mean dose to the Bladder (p = 0.0045) and Rectum (p = 0.0316). IGBT planning provided better coverage to the HRCTV (p = 0.04) and reduced doses to the Bladder (p = 0.0003) and Rectum (p = 0.0007) when total EQD2 doses were compared. In terms of dose received by 0.1cc, 1cc and 2cc of OARs, there was significant reduction by IGBT planning as compared to conventional planning. All patients received treatment according to IGBT planning. None of the patients reported acute grade 3 or 4 bladder or rectal toxicity at 2 months or 5 months post treatment CONCLUSIONS:Image–based achytherapy techniques allow us to precisely identify HR CTV and OARs. Dose optimization results in adequate target coverage and reduces delivery of unacceptable high doses to Organs At Risk