A prospective study of serum amylase levels in acute organophosphorous poisoning and its relationship with its severity and outcome.

Dr. N. Sukanya; Dr. P. Kesava Rao; Dr. Raghavaram Namburu

Volume : IX, Issue : IV, April - 2020

A prospective study of serum amylase levels in acute organophosphorous poisoning and its relationship with its severity and outcome.

Dr. N. Sukanya, Dr. P. Kesava Rao, Dr. Raghavaram Namburu

Abstract :

Introduction: Acute poisoning by organophosphosphorous Pesticides (OP) has reached epidemic proportions in most parts of the world, particularly in developing countries, where the toxicity of available poisons and paucity of appropriate medical facilities ensure a high fatality rate. Their ease of access and socio–cultural factors plays important role in choice of OP as a self–poison and the incidence is higher in young economically active group with a common fatality ratio of 20%. Case reports on acute pancreatitis following acute organophosphorus compound ingestion has been reported now and then, but regular studies with reference to Pancreatitis is not available in a serial manner. Hence an attempt was made to study Pancreatic involvement through biochemical means. Aims and Objectives Of The Study:– To estimate serum amylase levels in acute organophosphorus compound poisoning & to find out its relationship with Clinical severity and Outcome. MATERIAL AND METHODS: 1. STUDY DESIGN: An Analytical – A prospective Study, which was conducted through clinical examination and laboratory investigation, in a tertiary health care center. 2. PERIOD OF STUDY: The study was conducted for a period of 1 Year, i.e., 2018 to 2019. 3. STUDY AREA: The study was conducted in the department of General Medicine, Alluri Sitarama Raju Academy of Medical Sciences, Eluru, West Godavari district, Andhra Pradesh. Results: The majority of poisonings followed oral ingestion of liquid form. The incidence was higher (40%) in the age group of 21–30 followed by (35%)in the age group of 31–40.The most common reason for consumption was found to be the familial stress (65%) followed by financial stress (25%).Methyl parathion accounted for about 52.5% of intoxication .The commonest mode of intake was found to be poison along with water (67.5%)..The most troublesome complication was respiratory depression. Conclusions: In India, organophosphorus compounds cause more suicidal deaths among the earning and nonearning members of the society. The study showed that there was a significant correlation between markedly elevated amylase level and respiratory failure and therefore poor outcome.