A PROSPECTIVE STUDY TO SEE THE FEASIBILITY,TOXICITY AND EFFICACY OF TWICE WEEKLY INTERDIGITATED, INTRACAVITARY HIGH DOSE RATE BRACHYTHERAPY IN PATIENTS

Dr.Pritam Kr Sardar; Dr. Lekshmi R Shenoi; Prof (Dr) Siddharta Basu

Volume : IX, Issue : II, February - 2020

A PROSPECTIVE STUDY TO SEE THE FEASIBILITY,TOXICITY AND EFFICACY OF TWICE WEEKLY INTERDIGITATED, INTRACAVITARY HIGH DOSE RATE BRACHYTHERAPY IN PATIENTS

Dr. Pritam Kr Sardar, Dr. Lekshmi R Shenoi, Prof Dr Siddharta Basu

Abstract :

INTRODUCTION: Due to accelerated repopulation, the treatment of inoperable locally advanced Cervical carcinoma(LACC) should be completed within 8 weeks.In this study, we aim to further reduce the treatment time by interdigitating achytherapy with CCRT. AIMS AND OBJECTIVES:To assess the response according to RECIST criteria, version 1.1 and acute toxicities according to the Radiation Therapy Oncology Group [RTOG] criteria. MATERIALS AND METHODS:After undergoing metastatic work up, patients with histologically proved LACC were treated with CCRT.After 17 fractions eligible patients received HDR achytherapy twice weekly with a dose of 7Gy/fraction in 4 fractions.No radiation or chemotherapy were given on achytherapy days.During treatment, patients were reviewed weekly clinically and with blood reports and thereafter 6 weekly for 3 months and 3 monthly till the end of the study. RESULTS:Most common toxicity encountered during study was GI toxicty (81.1%) followed by haematological toxicity(48.6%) and skin toxicity(21.6%).Most grave toxicity was proctitis which was seen in 6 patients(16.2%).In this study overall response rate at 6 weeks after treatment completion(complete response and partial response) was 100% with complete response(86.5%) and partial response(13.5%).The median duration of follow–up after initial 6 weeks post–treatment assessment was 6 months.