Volume : VII, Issue : X, October - 2018

A RETROSPECTIVE COHORT STUDY ON TREATMENT OUTCOME FOR MDR–TB UNDER DOT– PLUS PROGRAM

Dr. Ashok Pralhad Waghmare

Abstract :

Background:

Multidrug–resistant tuberculosis (MDR–TB) and extensively drug–resistant tuberculosis (XDR– TB) are themajor public health problem that threatens the progress in disease care and control worldwide. The treatment of MDR–TB with second line drug is prolonged, complex, and expensive, having high rate of mortality along with the considerable rate of adverse effects.  But the treatment efficacyrates in MDR–TB are the key issue that cannot be ignored and this present study aims to evaluate the treatment outcomes and potential factors associated in patients with MDR–TB infections.

 

Method:– A retrospective cohort study was carried out among the enrolled in DOTS–Plus program withMDR–TB are287 no.of patients from 2012 to 2018 in Tuberculosis department,Ashwini Rural Medical College Hospital and Research Centre Kumbhari, Solapur, Karnataka, India. The patients  necessary information such as demographics, clinical parameters, if any previous TB treatment history  and treatment outcomes to Cat IV anti–TB therapy, any interruptions in treatment, adverse drug reactions, culture conversion etc. were evaluated from the records.

 

Results: Out of 287 patients, 32 (11.15%) had a successful cured after complete course of ATT). Remaining 153 patients had an unsuccessful outcome (death (27.53%), default (20.56%), failure or switched to Cat V (5.23%), and 75 patients (25.09%) are on treatment.

 

Conclusion:–The treatment success rate revealed that MDR‑TB patients has shown low treatment success rate. Patients still on treatment and High default treatment percentage had been observed, which could be the possible reason.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Ashok Pralhad Waghmare, A RETROSPECTIVE COHORT STUDY ON TREATMENT OUTCOME FOR MDR–TB UNDER DOT– PLUS PROGRAM, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-10 | October-2018


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