A REVIEW ON THE EXPRESSION, REGULATION AND FUNCTIONING OF THE Arc GENE COMPLEX IN CONEXT OF MEMORY FORMATION AND SYNAPTIC PLASTICITY

Rudrajit Sarkar; Dr. Dalia Mukhopadhay

Volume : VIII, Issue : II, February - 2019

A REVIEW ON THE EXPRESSION, REGULATION AND FUNCTIONING OF THE Arc GENE COMPLEX IN CONEXT OF MEMORY FORMATION AND SYNAPTIC PLASTICITY

Rudrajit Sarkar, Dr. Dalia Mukhopadhay

Abstract :

The Arc ( activity regulated cytoskeleton associated ) gene , located on chromosome 15 in mouse , chromosome 7 in rat and chromosome 8 in human genome , is conserved across verteate species and has low sequence homology to Spectrin . Arc encodes proteinaceous extracellular vesicles that pinch off from one neuron to another allowing them to communicate that may be key to long term memory formation and other neurological functions , and Arc knockout mice were observed having problems in long term memory formation . Arc is localised in the hippocampal region of the ain in higher verteates and plays a part in helping neurons form and eak connections over time as an animal�s nervous system adapts to a new environment . Changes in Arc mRNA or protein are connected with a number of behavorial changes including fear conditioning , contextual fear conditioning and inhibitory avoidance and has also been observed as a notable contributor in several neuro – degenerative diseases