A study of association between lipid parameters and disease activity assessed by using Bath Ankylosing Spondylits Disease Activity Index (BASDAI) in Ankylosing Spondylitis

Sarvagya Mishra; Abhishek Singhai; Prakash Joshi; Rajesh Kumar Jha

Volume : VII, Issue : V, May - 2018

A study of association between lipid parameters and disease activity assessed by using Bath Ankylosing Spondylits Disease Activity Index (BASDAI) in Ankylosing Spondylitis

Sarvagya Mishra, Abhishek Singhai, Prakash Joshi, Rajesh Kumar Jha

Abstract :

Introduction: Ankylosing Spondylitis (AS) is an inflammatory disorder of unknown etiology affecting primarily the axial skeleton, peripheral joints and extraarticular structures, beginning in the second or third decade; male–to–female prevalence being 2:1 and 3:1.Aim of our study was to assess association between lipid parameters and disease activity assessed by using Bath Ankylosing Spondylits Disease Activity Index (BASDAI) in Ankylosing Spondylitis.

Materials & Methods:The study group included 30 patients with a known history or clinical features suggestive of Ankylosing Spondylitis. The control group included 30 normal adult patients without any previous history.All patients included in the study underwent detailed clinical history, analysis, physical examination and necessary investigations. The study was approved by ethical committee and an informed written consent was obtained from every patient. Disease activity was measured using BASDAI.

Results:In our study, we included a total no. of 60 patients, out of which 30 cases were the patients with a known history or clinical features suggestive of AS. A total of 30 normal adults who were age and sex matched with the study group were taken as controls. In our study, cholesterol (r=0.515, p=0.004), Triglycerides (r=0.500, p=0.005) and LDL (r=0.517, p=0.003) was positively correlated with BASDAI and the difference was found to be statistically significant. HDL (r=0.627, p=.000) was negatively correlated with BASDAI but the difference was statistically significant.

Conclusion:Patients with AS have higher lipid abnormalities than shown by controls. Every effort should be made in order to control inflammation and traditional risk factors in this population, to avoid the consequences of accelerated atherogenesis. This should provide impetus to early intervention strategies to prevent accelerated atherosclerosis which would help in reducing the cardiovascular morbidity and mortality associated with this disease.