A STUDY OF BACTERIAL PROFILE AND ANTIBIOTICS RESISTANCE PATTERN OF VARIOUS CLINICAL ISOLATES IN WOUND SWABS OF HOSPITALISED BURN PATIENTS AT TERTIARY CARE HOSPITAL

Shruti Sharma; Mahesh Kumar; Geeta Parihar

Volume : V, Issue : III, March - 2016

A STUDY OF BACTERIAL PROFILE AND ANTIBIOTICS RESISTANCE PATTERN OF VARIOUS CLINICAL ISOLATES IN WOUND SWABS OF HOSPITALISED BURN PATIENTS AT TERTIARY CARE HOSPITAL

Shruti Sharma, Mahesh Kumar, Geeta Parihar

Abstract :

Introduction: Burn injuries are common throughout the world, especially in developing and underdeveloped countries. The survival rate for burn patients has substantially improved in the past several decades due to advancement in medical care and centers specialized in burn care; however due to the increased survival rates, infections are becoming a leading cause of mortality rather than hypovolaemia and shock. Currently 75% of all deaths are due to infectious complications such as sepsis and bacteremia 1 Aim & objectives: This study was conducted for isolation, identification, determination of frequency, spectrum and antibiotic sensitivity pattern of aerobic bacterial isolates from the wound swab samples of burn patients. Material Method: Study was carried out in Department of Microbiology, over a period of one year, from May 2014 to May 2015. A total of 100 patients of all age groups and both sexes admitted in our Burn Care Unit, from J.L.N Hospital, were selected for this study. Result and Observation: From 100 patients, a total of 133 samples were taken and 156 organisms were isolated. The overall isolation rate was 87.96%. Solitary isolates (58%) were seen more commonly than multiple isolates (30%). Overall, Gram negative organisms (66.66%) were more common than Gram positive organisms (33.33%). Pseudomonas (P. aeruginosa and Pseudomonas species) (42.94%) was the most common isolate followed by Staphylococcus aureus (19.23%), Klebsiella pneumoniae (14.74%), Coagulase Negative Staphylococcus (14.10%), Escherichia coli (5.12%), Proteus mirabilis (2.04%), Citrobacter freundii (1.28%). Imipenem (100%) was the most effective drug against the Pseudomonas aeruginosa and other Pseudomonas species. Imipenem (100%) was also the most effective drug against the other Gram Negative Organisms. It was seen that vancomycin and linezolid (100%) were the most effective drugs for the Gram positive organisms. Incidences of Methicillin Resistant Staphylococcus aureus were 37% incidences of Methicillin Resistant CONS were 18.18%. Conclusion: The routine microbiological surveillance and adherence to restrictive antibiotic policy may be useful in reducing infection related mortality and morbidity in burn patients. Our results may be of help in providing useful information regarding formulation of effective guidelines for therapy, thus improving overall infection related morbidity and mortality