Volume : VII, Issue : XI, November - 2018

A study of C-reactive protein in Acute myocardial infarction

Dr. Arumugam. M. A, Dr. Ramesh Subramanian

Abstract :

 Background: In Acute MI various biochemical substances rise in the serum .Study of C–Reactive protein is helpful not only in diagnosis but also in assessing the complications and efficacy of thrombolytic therapy in Acute myocardial Infarction Aim of the study :To assess the efficacy of thrombolysis in acute myocardial infarction after streptokinase injection  with  C–reactive protein estimation  and to compare with clinical and ECG parameters. Materials and method: 50 patients admitted for Myocardial infarction in ICCU with typical chest pain and definitive ECG changes of  ST segment elevation  in at least two leads. Vital parameters were recorded. Serial ECG charges were followed in all patients. Blood sample drawn between 6 and 12hrs , 14 to30 hrs, 24to 30 hrs  and 48–60 hrs after the onset of chest pain .Fifth Sample drawn at the end of one  week. The sample was tested for C–reactive protein level by latex agglutination test. 20 patients who attended the outpatient department were kept as control. Results: Study population :50 . Age group: 30 to 76 yrs. Males:42 Females:8,AnteriorWall:34 Inferior Wall:16. Treatment with streptokinase:20. Male:17, Female:3. Anterior Wall:16 Inferior Wall:4. Efficacy of Thrombolytic therapy as assessed by relief of chest pain and reduction of ST segment elevation by 50% .C–reactive protein level started raising after 12 hrs in most of the patients. Conclusion: C–Reactive protein level reaching its peak level at 48–60 hrs in patients who were not given streptokinase and returned to normal on 7th day in this study and hence  useful in confirming the diagnosis of myocardial infarction. The fall in C–Reactive Protein Level from 24–30 hrs to the level at 48–60 hrs in patients with streptokinase showed higher sensitivity of thrombolytic efficacy than clinical and ECG parameters.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

A study of C-reactive protein in Acute myocardial infarction , Dr.Arumugam.M.A, Dr.Ramesh Subramanian , INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7|Issue-11| November-2018

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