A STUDY OF CLINICAL PROFILE OF ACUTE CORONARY SYNDROME AND ITS CORRELATION WITH SERUM FREE TESTOSTERONE LEVEL IN MEN IN TERTIARY CARE HOSPITAL OF UTTARAKHAND

Dr Ashwani Chauhan; Dr S P Singh; Dr Sumita Sharma; Dr Saurabh Agarwal; Dr Amit Varma

Volume : VII, Issue : V, May - 2018

A STUDY OF CLINICAL PROFILE OF ACUTE CORONARY SYNDROME AND ITS CORRELATION WITH SERUM FREE TESTOSTERONE LEVEL IN MEN IN TERTIARY CARE HOSPITAL OF UTTARAKHAND

Dr Ashwani Chauhan, Dr S P Singh, Dr Sumita Sharma, Dr Saurabh Agarwal, Dr Amit Varma

Abstract :

Serum free testosterone has been extensively studied for its role as immunomodulatory effect,anti–inflammatory action and its favourable impact on lipid profile , blood pressure. Earlier higher levels of testosterone were thought to have deleterious effect on cardiovascular system, in last few years there has been studies suggesting low testosterone levels are associated with increase prevalence of cardiovascular disease. Aims & Objectives:1. To estimate s. free testosterone level in male patient suffering acute coronary syndrome(ACS). 2.To correlate the association of s. free testosterone level with pattern of ACS. 3.To correlate s. free testosterone level with mortality and morbidity in male patients presenting with ACS. Material & Methods: Source: This study was carried out in tertiary hospital of Uttarakhand included 100 case and 25 controls.Diagnosis of ACS was confirmed by ECG, troponin I and CAG in each case. A baseline serum Free Testosterone level was evaluated at the time of admission. OBSERVATION: Mean age in case and control was 48.24�10.84 and 46.88�10.94 respectively. Mean BMI 23.5�2.62 and 22.9�3.26 respectively. Low serum free testosterone levels were found in 61% of cases and 8% of control group. Difference of serum free testosterone levels among cases and controls was found to be statistically significant (p<0.05). We found significantly Low serum free testosterone in different types of ACS viz STEMI, NSTEMI and Unstable Angina as compared to control. (p<0.05). We also tried to correlate serum free testosterone levels with different lipid parameters but the difference among the groups was insignificant.

Conclusion: s. free testosterone levels were significantly low in patients with ACS as compared to control. Mean serum free testosterone were lower in STEMI group as compared to NSTEMI though the difference was statistically insignificant, however it did not show any correlation with the pattern of myocardial infarction.