A Study of Clinicopathological and Radiological correlation of Breast diseases

Dr. Jayashri Pandya; Dr. Sudatta Waghmare; Dr. Ajeet Ramamani Tiwari; Dr. Makrand Thakre; Dr. Anand Dugad

Volume : VI, Issue : IV, April - 2017

A Study of Clinicopathological and Radiological correlation of Breast diseases

Dr. Jayashri Pandya, Dr. Sudatta Waghmare, Dr. Ajeet Ramamani Tiwari, Dr. Makrand Thakre, Dr. Anand Dugad

Abstract :

Introduction: Breast lump among females, is a fairly common complaint in every surgical out patient department. Breast lump have a variety of etiologies ranging from benign to malignant. These patients are usually evaluated on basis of Triple assessment namely clinical examination, imaging mammography/east ultrasonography and FNAC/core biopsy.

Aims and Objectives: To Find Correlation between Clinical Breast examination, Radiological assessment and Histopathological assessment of east diseases

Materials and Methods: This prospective study was conducted at a tertiary teaching center from 1 January 2015 to 31 July 2016. A total of 394 patients who presented with east lump in the Breast Diseases Unit of the Institute during this period were enrolled by simple random sampling method without any bias. These patients were examined with a detailed history and clinical examination. Upon clinical assessment, radio and pathological assessment was done as deemed appropriate.

Results: 284 (72.1%) out of 394 were classified under benign lesions clinically and rest 110 (27.9%) as malignant. Radiological assessment was performed for 331 patients . 248 (74.9%) patients were diagnosed as radiologically benign and remaining 83(25.1%) patients were found to be malignant. The association between radiological assessment and clinical assessment was found to be statistically significant with chi square value 201.911 and p value 0.001. Histopathological diagnosis was made for 200 patients of which 103(51.5%) were benign and 97(48.5%) malignant cases. The association between histopathological assessment and clinical assessment was found to be statistically significant with chi–square value 141.160 and p value 0.001. The correlation between clinical examination and radiological examination, histopathological and radiological examination and that between clinical and histopathological examination were found to be statistically significant with p value 0.001. Clinical and radio–logical assessment are similar in terms of sensitivity (92.8% v/s 94.7%), Positive predictive value (90.9% v/v 87.8%), negative predictive value (93.1% v/s 93.5%) and false negative rates (7.2% v/s 6.5%).

Conclusion: The high sensitivity, negative and positive predictive values of Clinical Breast examination, radiological and histopathological assessment continue to uphold this triad as the gold standard for assessment of east diseases.