A Study of Hematological Profile with Special Reference to Thrombocytopenia in HIV Infected Persons with and without Antiretroviral Therapy

Bhavik S. Shah; Swati C. Aundhakar

Volume : VI, Issue : V, May - 2017

A Study of Hematological Profile with Special Reference to Thrombocytopenia in HIV Infected Persons with and without Antiretroviral Therapy

Bhavik S. Shah, Swati C. Aundhakar

Abstract :

Introduction: HIV attacks the body�s immune system and disables the immune system to defend the body against diseases and tumors. Aims :To study hematological profile of HIV infected patients and laboratory determinations of thrombocytopenia and correlate with CD4 lymphocyte count. Methods :This prospective non interventional observational study was carried out in KIMS, during period of 18 months from 1st October 2014 to 31st march 2016. 123 cases of HIV were included in the study. Results : Out of 123 patients studied,71 were males and 52 females.The mean Hb% for males in the present study is 9.7 gms% and for females is 8.1 gms%. The study have shown leucopenia in 57.7% , neutropenia in 3.3%, lymphopenia in 49.6% , and thrombocytopenia in 74% cases.Microcytic hypochromic anemia seen in 48.8% cases, dimorphic anemia in 14.6% cases and pancytopnia was seen in 13.8% cases.In males 55 cases having AIDS, 83.6% cases were having Hb% less than 13 gm%. In females 44 cases having AIDS, 90.9% cases were having Hb% less than 12 gms%. Out of 99 cases having AIDS, 57.6% cases were having leucopenia,52.3% cases had lymphopenia and 71.7% cases had thrombocytopenia.51.5% cases had mircrocytic anemia.58.5% cases were on ART in which 75% cases had thrombocytopenia and 23.6% had leucopenia. CONCLUSION :Out of 123 cases, the commonest haematological manifestations found were microcytic hypochromic anemia, leucopenia and thrombocytopenia. The frequency and severity of these hematological manifestations increased with decline in CD4 count.