A STUDY OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE PATIENTS AND ITS RELATION TO LEFT VENTRICULAR MASS

Salla Surya Prakasarao; Suma Pusapati; Kartheek Pyla; Srikanth Gummadi

Volume : VII, Issue : III, March - 2018

A STUDY OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE PATIENTS AND ITS RELATION TO LEFT VENTRICULAR MASS

Salla Surya Prakasarao, Suma Pusapati, Kartheek Pyla, Srikanth Gummadi

Abstract :

Aim and Objective: The study was conducted with an aim to evaluate hypertensive patients with diastolic dysfunction and its correlation with left ventricular mass by echocardiography and electrocardiography.

Materials and Methods: This study was conducted in NRI Institute of Medical Sciences, Visakhapatnam, India. All 50 subjects for the study were inpatients, with hypertension of less than 5years duration. Each subject was evaluated with echocardiography , pulse Doppler study and ECG for evidence of diastolic dysfunction and LVH.

Results: The mean age of the subjects was found to be 66.88 (SD� 11.286). There was no significant correlation found between left ventricular hypertrophy and gender in our study(56% males, 44% females). All of the 50 (100%) patients had grade 1 LV diastolic dysfunction, which was statistically significant (p=0.00001). Grade 1 LV diastolic dysfunction was observed as a reversal of the ratio of early mitral inflow velocity–E–wave to the late

inflow velocity A– wave. Of the 50 patients, 10(20%) patients showed evidence of left ventricular hypertrophy on ECG, while 40 (80%, p=0.00001) did not have the findings. 10(20%) of the patients with diastolic dysfunction showed evidence of left ventricular hypertrophy on 2D echocardiography as opposed to 40 (80% p=0.00001) who did not. 2(4%) of the 50 patients were type 2 diabetes mellitus and 3 (6%) out of the 50 subjects were patients of chronic kidney disease, both of which were not statistically significant (p>0.005) and did not influence the outcome of the study.

Conclusion: We concluded that diastolic dysfunction was an early pathological consequence in hypertensive disease and its occurrence preceded that of left ventricular remodeling or hypertrophy as evidenced by ECG and echocardiography.