Volume : VII, Issue : VII, July - 2018

A STUDY OF THE EXPRESSION OF EGFR AND TTF1 ON PRIMARY LUNG CARCINOMA

Dr. Lekha K. Nair, Dr . Fathima Nasrina, Dr. Ashiq Siddique . N

Abstract :

 Background : Since it is an era of targeted therapies, identification of molecular differences between the specific subtypes of lung carcinomas are

necessary. So the pathologists are challenged with the need to offer the clinicians a more detailed classification of lung carcinomas with the help of
immunohistochemistry.
Methodology:The study is a cross sectional study with immunohistochemical analysis of 41 lung biopsies of primary lung carcinomas received in
our department. The expression of EGFR and TTF1 were analysed and scored by H score and diffuse nuclear positivity respectively.
Results: 70% (14 out of 20cases) of adenocarcinoma and 25% (1 out of 4 cases) of small cell carcinoma shows TTF 1 positivity. None of the
squamous cell carcinoma is TTF 1 positive. In the present study 94% (16 out of 17cases) of squamous cell carcinoma and 85% (17 out of 20 cases)
of adenocarcinoma show EGFR positivity. None of the small cell carcinoma show EGFR positivity. Majority of cases of primary lung
adenocarcinomas showed both EGFR and TTF1expression(65%) , showing a good correlation between the two.
Conclusions:Epidermal growth factor receptor protein expression is more in squamous cell carcinoma. Thyroid transcription factor 1 expression
is more in adenocarcinoma. Majority of cases of primary lung adenocarcinomas show both EGFR and TTF 1 expression.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

DR. LEKHA K. NAIR, DR .FATHIMA NASRINA, DR.ASHIQ SIDDIQUE .N, A STUDY OF THE EXPRESSION OF EGFR AND TTF1 ON PRIMARY LUNG CARCINOMA, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-7 | July-2018


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