A STUDY ON DOCETAXEL–INDUCED LIPID PEROXIDATION USING 4–HYDROXY–2–NONENAL AS MODEL MARKER: PROTECTIVE ROLE OF WATER EXTRACT OF SPIRULINA PLATENSIS

Supratim Ray

Volume : IV, Issue : III, March - 2015

A STUDY ON DOCETAXEL–INDUCED LIPID PEROXIDATION USING 4–HYDROXY–2–NONENAL AS MODEL MARKER: PROTECTIVE ROLE OF WATER EXTRACT OF SPIRULINA PLATENSIS

Supratim Ray

Abstract :

The aim of the study was to investigate the antiperoxidative potential of water extract of Spirulina platensis on docetaxel–induced lipid peroxidation using 4–hydroxy–2–nonenal as model marker. Goat liver was used as a source of liver. The results showed that docetaxel had the capacity to induce lipid peroxidation on goat liver tissue homogenates. The study also revealed the antiperoxidative potential of water extract of Spirulina platensis on docetaxel–induced lipid peroxidation. Interpretation of the results is supported by analysis of variance and also by statistical multiple comparison analysis using least significant different procedure.