A Study on Efficacy of CLOZAPINE in  Treatment Resistant Schizophrenia.

Dr. Aamani M; Dr. Kalyan Kandra; Dr. R. Somasundara Babu

Volume : IV, Issue : VI, June - 2015

A Study on Efficacy of CLOZAPINE in Treatment Resistant Schizophrenia.

Dr. Aamani M, Dr. Kalyan Kandra, Dr. R. Somasundara Babu

Abstract :

AIMS AND OBJECTIVES : To study the efficacy of CLOZAPINE in Treatment Resistant Schizophrenia.To evaluate the association of schizophrenia with socio demographic characteristics and adverse effects during the course of treatment with Clozapine. MATERIAL & METHODOLOGY : A short term, cross sectional, prospective & non comparative study was conducted among inpatients from Department of Psychiatry in Alluri Sita Rama Raju Academy of Medical Sciences, Eluru for a duration of 8 weeks. RESULTS : • The mean positive symptom score showed a gradual improvement from 17 to 7 by the end of 8weeks which was found to be statistically significant (t=18.698, p<0.01). • The mean negative symptom score showed a gradual improvement from 24 to 10 by the end of 8 weeks which was found to be statistically significant (t=18.880, p<0.01). • The mean general psychopathology score showed a gradual improvement from 23 to 9 by the end of 8 weeks which was found to be statistically significant (t=25.225, p<0.01). Common mild adverse effects were encountered but none of the patients treated with Clozapine developed Extra pyramidal symptoms, Agranulocytosis , Seizures & Myocarditis CONCLUSION : Our study concluded that Clozapine is beneficial, relatively well tolerated and the ideal drug for Treatment Resistant Schizophrenia. However, attention should be paid to patients� adverse events and precautions against Agranulocytosis should be taken.