A Study on Immune Response of Hepatitis  B Vaccine Among Medical Interns

M. Manimaran; S. Chitra; R. Murali; M. Malarvizhi; A. R. Venkateshwaran; M. S. Revathy

Volume : III, Issue : I, January - 2014

A Study on Immune Response of Hepatitis B Vaccine Among Medical Interns

M. Manimaran, S. Chitra, R. Murali, M. Malarvizhi, A. R. Venkateshwaran, M. S. Revathy

Abstract :

Hepatitis B is the most important infectious occupational hazard which Indian medical students encounter. As the universal precaution is not effectively followed among medical students, studies are needed to document the compliance to and effectiveness of hepatitis B vaccination.Objectives are to study the immune response to HBV vaccination and to correlate the antibody response with the duration of vaccination. In this cross sectional study 150 medical interns were included. Single blood sample was drawn and anti HBs titration was done by chemiluminescence assay.Statistical analysis was done using SPSS for windows version 16.0.Vaccination rate was 94.6% and efficacy of vaccination was 88%. There was no association between gender and anti HBs titer (p value 0.13).Declining of anti HBs titer with duration of vaccination was significant (p=0.05). As fall in anti HBs titer with the duration of the vaccination is an established fact, also considering Health care workers as the high risk population booster dose can be recommended to them.