Volume : IV, Issue : IV, April - 2015

A Study on Relationship Between the Presence of Thyroid Antibody (Antitpo–Ab) in Early Antenatal Period and the Development of Thyroid Dysfunction at Post Partum Period.

Dr Yasmin Syed, Dr Asrar Ahmed

Abstract :

Postpartum thyroiditis (PPT) is a syndrome of transient or permanent thyroid dysfunction occurring in the first

year after delivery and based on an autoimmune inflammation of the thyroid
Objectives: To find out any possible relationship between the presence of thyroid antibody (antiTPO-Ab) in early antenatal period and the
development of thyroid dysfunction at post partum period.
Methods : Sixty three women of 16 to 18 weeks of pregnancy were screened and studied. The women were followed up till the sixth post partum month. Statistical analysis was done by Fisher’s Exact test and Mann-Whitney U test. Results: Anti TPO-antibody positivity in antenatal
women is 9.52%.TPO antibody positive women when compared with negative women showed significant differences in the development of
post partum thyroid dysfunction (33.33% vs. 1.75%, P=0.022), mean serum TSH level (2.7 vs 1.72, P=0.01) and history of miscarriages (66.67%
vs 14.03%, P=0.01). Conclusions : The risk of development post partum thyroid dysfunction increases significantly in women with positive
TPO antibody and mean serum TSH level >2mU/1 measured in 16 to 18 weeks of pregnancy. Screening of women with other immunological
disorders or history of miscarriage can be done during antenatal period.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr Yasmin syed,Dr Asrar Ahmed A Study on Relationship Between the Presence of Thyroid Antibody (Antitpo–Ab) in Early Antenatal Period and the Development of Thyroid Dysfunction at Post Partum Period. International Journal of Scientific Research, Vol : 4, Issue : 4 April 2015


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