Volume : IV, Issue : II, February - 2015

Acute fatty liver of pregnancy: A Rarity.

Dr. Bandi Jyoti, Dr. Umashree G

Abstract :

Acute fatty liver of pregnancy (AFLP) is an uncommon but potentially fatal complication that occurs in the third trimester or early postpartum period. It was first described in 1940 by Sheehan (1) as an “acute yellow atrophy of the liver”. AFLP is characterized by microvesicular fatty infiltration of hepatocytes without any inflammation or necrosis. It has an incidence of approximately one in 10,000 to 15,000 pregnancies (2). In the past, maternal and perinatal mortality were reported to be as high as 75% and 85%, respectively (3). More current data showed that with prompt diagnosis and treatment, the maternal and perinatal mortality have greatly decreased, to approximately 18% and 23%, respectively (1,4,5). Despite the accumulation of data about this condition, the exact pathogenesis has yet to be determined. At present, supportive care and expeditious delivery remain the best treatment. The present article provides a review of AFLP, including etiology, pathophysiology, clinical presentations, diagnosis and management.We are reporting a case of 20 year old G2A1 who presented to us with history of fever and was later diagnosed to be having acute fatty liver which is a rare entity

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr.Bandi Jyoti,Dr.Umashree G Acute fatty liver of pregnancy: A Rarity International Journal of Scientific Research, Vol : 4, Issue : 2 February 2015

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