Acute sensory axonal neuropathy (ASAN): An unusual pure sensory variant of Guillain–Barre Syndrome associated with IgM auto antibodies against GM1.

Dr Sandhya Manorenj; Dr Muralikrishna P.S; Dr Sravan Kumar; Dr Navya Sagari

Volume : VI, Issue : IX, September - 2017

Acute sensory axonal neuropathy (ASAN): An unusual pure sensory variant of Guillain–Barre Syndrome associated with IgM auto antibodies against GM1.

Dr Sandhya Manorenj, Dr Muralikrishna P. S, Dr Sravan Kumar, Dr Navya Sagari

Abstract :

Sensory Guillain–Barr� syndrome (GBS) is a rare, acute demyelinating neuropathy that presents clinically with involvement of the sensory peripheral nerves only. A 21–year old lady presented with an acute onset of symmetrical sensory abnormalities of all extremities. Neurological examination showed normal motor strength throughout with areflexia, reduced pin–prick and loss of temperature sensation in distal extremities and antalgic gait. A lumbar puncture performed 2 weeks after onset demonstrated albuminocytologic dissociation. Electrophysiology showed sensory neuropathy of axonal type with normal motor nerves studies. Antiganglioside antibodies testing revealed IgM antibodies against GM1. Patient showed dramatic clinical recovery following treatment with intravenous immunoglobin (IVIG).The present case highlights pure sensory variant of GBS with axonal involvement associated with IgM antibodies against GM1.