Volume : VII, Issue : II, February - 2018
ACUTE VIRAL HEPATITIS AND ITS ASSOCIATION WITH LIPID PROFILE
Jaya Pathak, Nibha Jain, Iti Parikh, Darshankumar M Raval, Zeal Kishor Thakkar
Abstract :
Background
Acute viral hepatitis is a parenchymal liver disease, characterized by widespread liver damage in which variable number of hepatocytes undergo necrosis. This results in different pattern of lipid abnormalities, which may be a prognostic factor in deciding the severity of acute Viral Hepatitis.
Aims
To know the pattern of lipid anomalies and severity of hepatic damage in acute viral hepatitis from the quantum of lipid profile. In addition, to find out if lipid profile helps in prognostication.
Methods
Case control study of patients of acute viral hepatitis was done. Seventy cases of acute viral hepatitis were studied along with seventy age and sex matched controls. All routine investigations, serological viral markers and fasting serum lipid profiles were analysed .All data was analysed using t test. A p value of <0.05 was considered statistically significant.
Results
Baseline parameters were similar between cases and control .On compå the results of lipid profiles in both , the Serum Triglycerides , Cholesterol and LDLc levels were significantly raised (p<0.001) and HDLc levels were significantly decreased(p<0.001) in acute viral hepatitis when compared to controls. HDLc was significantly lower (p<0.001) in cases of acute viral hepatitis with hepatic encephalopathy in contrast to those without it.
Conclusion
Triglycerides Cholesterol and LDLc were significantly raised and HDLc level were significantly decreased when compared to controls. HDLc was significantly low in cases with hepatic encephalopathy. In conclusion, estimation of serum HDLc allows better assessment of hepatic function and evaluation of prognosis of patients with acute viral hepatitis.
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DOI : 10.36106/ijsr
Cite This Article:
JAYA PATHAK, NIBHA JAIN, ITI PARIKH, DARSHANKUMAR M RAVAL, ZEAL KISHOR THAKKAR, ACUTE VIRAL HEPATITIS AND ITS ASSOCIATION WITH LIPID PROFILE, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH :
Volume-7 | Issue-2 | February-2018
Number of Downloads : 459
References :
JAYA PATHAK, NIBHA JAIN, ITI PARIKH, DARSHANKUMAR M RAVAL, ZEAL KISHOR THAKKAR, ACUTE VIRAL HEPATITIS AND ITS ASSOCIATION WITH LIPID PROFILE, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-2 | February-2018
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