Volume : VIII, Issue : VIII, August - 2019

Advances in type 1 retinopathy of prematurity management, a literature review

Arwa Azmeh, Huda Nasani

Abstract :

Purpose: To investigate recent advances in treatment and follow up of type 1 Retinopathy of Prematurity (ROP) using intravitreal anti–vascular endothelial growth factor (anti–VEGF) as monotherapy or in combination with laser photocoagulation (LPC). Methods: Search was conducted in Medline/PubMed database using keywords “anti–VEGF for retinopathy of prematurity, laser photocoagulation for retinopathy of Prematurity, Retinopathy of prematurity”. Full texts of 99 original articles directly related to the aim of the review were used. Results: In recent years, there has been increased interest in the use of anti VEGF as monotherapy or in combination with laser photocoagulation. Fluorescein angiography (FA) findings are helpful during follow–up to reveal areas of avascular retina or signs of reactivation that necessitates further laser photocoagulation following intravitreal anti VEGF treatment. Ultra–low dose of intravitreal Bevacizumab as much as 2.5% of adult dose may be effective in treatment of zone I and posterior zone II ROP except for Aggressive Posterior Retinopathy of Prematurity (APROP) which needs higher doses as high as 50% of adult dose Conclusion: Based on current evidence, combination of intravitreal anti–VEGF and prophylactic laser may minimize the risk of early or late recurrence and development of progressive retinal detachment (RD). Future prospective studies for defining lowest appropriate anti–VEGF intravitreal doses as well as refining retreatment guidelines using FA findings are needed.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

ADVANCES IN TYPE 1 RETINOPATHY OF PREMATURITY MANAGEMENT, A LITERATURE REVIEW, Arwa Azmeh, Huda Nasani INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-8 | August-2019

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