Alarming increase in drug resistance amongst the bacterial and fungal isolates of blood culture in a tertiary care centre of North India : time to switch for antibiotic holiday

Nidhi Negi; Bipin Chandra Pokhriyal; Iva Chandola; V. K. Kataria

Volume : VIII, Issue : II, February - 2019

Alarming increase in drug resistance amongst the bacterial and fungal isolates of blood culture in a tertiary care centre of North India : time to switch for antibiotic holiday

Nidhi Negi, Bipin Chandra Pokhriyal, Iva Chandola, V. K. Kataria

Abstract :

Background: Bloodstream infections (BSI) are an important cause of morbidity and mortality both in developed and developing part of world. They constitute an important part of health care associated infections and require adequate and early antimicrobial therapy even before the blood culture reports are available in laboratory. Therefore it has become mandatory to analyse the prevalent microorganisms responsible for blood stream infections as well as the pattern of antimicrobial drug resistance.

Methods: A total of 3931 blood culture samples were included in the study & tested for their positivity by bac T alert 3d system and antimicrobial susceptibility by VITEK 2.

Results: A total of 520 blood culture samples came out to be positive. Isolates consisted of Escherichia coli (21%) , Candida spp (18%), Acinetobacter baumanii (16%), Salmonella Typhi (13%), Klebsiella pneumoniae (12%), Pseudomonas aeruginosa (9%), Enterococcus spp (7%) and Staphylococcus aureus (4%). Antibacterial as well as antifungal susceptibility pattern was analysed for bacterial and fungal isolates respectively.

Conclusion: there is increasing prevalence of Gram negative bacteremia in hospital settings. Inspite of the advances in antimicrobial therapy, the drug resistance is prevailing rampantly especially for the polypeptide group of drugs like colistin