Volume : III, Issue : X, October - 2014

Allergic Reactions to Local Anesthetics–Observational Study

Grazyna Michalska Krzanowska

Abstract :

To analyze the spectrum of adverse reactions to local anesthetics. Twenty consecutive patients due to severe reaction observed after administration of local anesthetic. Skin prick tests, intradermal tests, and progressive provocation challenge with suspected local anesthetic and its commercially available replacers were conducted 4 weeks to 2 months following the episode of post–drug reaction. The list of suspected local anesthetics included lidocaine (n=11), mepivacaine (n=4), articaine (n=3), bupivacaine and tetracaine (n=1 each). The safety of mepivacaine was confirmed in 5/7, bupivacaine in 6/7, and lidocaine in only 1/3 tested subjects. One mepivacaine–sensitive individual and one patient sensitive to lidocaine further proved tolerant to bupivacaine. One subject with bupivacaine hypersensitivity showed tolerance to mepivacaine. There were six cases of cross–reactivity between various anesthetic agents. Comprehensive evaluation of potential hypersensitivity to LA should include analysis of patient history and medical documentation, testing for immediate reaction to a given anesthetic preparation, as well as cross–reactivity testing.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Grazyna Michalska-Krzanowska Allergic Reactions to Local Anesthetics � Observational Study International Journal of Scientific Research, Vol : 3, Issue : 10 October 2014

Number of Downloads : 1046

References :