Volume : V, Issue : VIII, August - 2016

Altered metabolic profile in newly diagnosed primary hypothyroidism

Dr Sridevi V, Dr Vinit Anand, Dr Mahendrappa

Abstract :

 Hypothyroidism is a clinical syndrome characterized by the clinical and biochemical manifestation of thyroid hormone deficiency in the target tissue, leading to generalized slowing of all metabolic processes. By affecting the metabolism of lipids, thyroid hormones accelerate the process of atherogenesis and it increases the cardiovascular risk. Thyroid dysfunction causes remarkable changes in glomerular and tubular functions and electrolyte and water homeostasis. Thyroid hormone is involved in haemoglobin synthesis and by affecting the hematopoietic process, hypothyroidism results in anaemia through slowing the oxygen process. Aims and objectives: To estimate serum lipid profile, serum creatinine, uric acid, Haemoglobin levels in hypothyroid patients and to compare it with euthyroid normal controls. Materials and methods: We measured serum lipid profile [Total cholesterol (TC), Triglyceride (TG), HDL–Cholesterol (HDL–C), LDLCholesterol (LDL–C), VLDL–Cholesterol (VLDL–C)] serum creatinine, uric acid and haemoglobin (Hb) levels in 100 newly diagnosed primary hypothyroid patients and compared it with 100 euthyroid normal controls. Fasting venous sample was used for analyzing the parameters. Statistical analysis was done using student‘t’ test. Pearson’s correlation coefficient test was done to establish the relationships between the parameters. Results: The serum creatinine, uric acid, TC, TG, LDL–Cholesterol, VLDL–Cholesterol were significantly elevated (p<0.001) and HDLCholesterol and Hb levels were significantly decreased (p<0.001) in primary hypothyroid cases when compared to euthyroid controls Conclusion: Hypothyroidism is associated with metabolic derangements and multisystem approach is required to treat patients with hypothyroidism.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr Sridevi V, Dr Vinit Anand, Dr Mahendrappa Altered metabolic profile in newly diagnosed primary hypothyroidism International Journal of Scientific Research,Volume : 5 | Issue : 8 |August 2016

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