An efficient synthesis and biological screening of some new 2chloroacetyl amino6substituted benzothiazoles.

Anil B. Chidrawar

Volume : V, Issue : IX, September - 2016

An efficient synthesis and biological screening of some new 2chloroacetyl amino6substituted benzothiazoles.

Anil B. Chidrawar

Abstract :

A Literature survey indicates that benzothiazole derivatives possess different pharmacological and biological activities; which of most potent activity are anti–inflammatory and anti–bacterial activity. The starting product is 6–substituted–1,3–benzothiazol–2–amine was prepared from 4–substituted anilines and potassium thiocyanate in one step. Substituted Benzothiazolyl–2–amines were reacted with chloroacetyl chloride to yield 2–chloro acetyl amino–6–substitued benzothiazoles, which were reacted with 2–mercaptobenzothiazole and 2–hydrazinobenzothiazole gave 2–(1,3–benzothiazol–2–yl thio)–N–(6–substitued–1,3–benzothiazol–2–yl)acetamides and 2–[2–(1,3–benzothiazol–2–yl)hydrazino]–N–(6–methyl–1,3–benzothiazol–2–yl)acetamides respectively. The synthesized compounds were characterized by elemental analysis and spectral data