An Immunological evaluation of squamous cell carcinoma oral cavity, pharynx and larynx by skin window test

Dr Chandra Bhan; Dr J.P. Purohit; Dr Mayank Singh

Volume : IV, Issue : XII, December - 2015

An Immunological evaluation of squamous cell carcinoma oral cavity, pharynx and larynx by skin window test

Dr Chandra Bhan, Dr J. P. Purohit, Dr Mayank Singh

Abstract :

Neoplastic cells are antigenically different from normal cells. The antigens of tumour cells induce cellular and humoral responses. Squmaous cell carcinoma of head and neck are associated with the impairments of cellular immunity. Cellular response is mainly responsible in effecting cytotoxic immunological reaction against the neoplasm. The assessment of cellular response in vivo is being done with skin sensitisation test such as the Skin window test, Mantoux test and DNCB (dinitrochlorobenzene) test. The responses in the patients are assessed and co–related with histological grading, clinical staging and mode of treatment of the tumour. This assessment helps in understanding the immunological condition and prognosis of the disease in patients suffering from cancer of the oral cavity, pharynx and larynx.