An Observational Study To Evaluate Efficacy Of Pretreatment With Lignocaine And Ketamine To Prevent Propofol Injection Pain In Patients Undergoing Surgery Under General Anaesthesia

Dr. Atlanta Talukdar; Dr. Akhilesh Chhaya; Dr. Tejash H Sharma; Dr. Priya Kishnani; Dr. Dinesh Chauhan

Volume : IX, Issue : VI, June - 2020

An Observational Study To Evaluate Efficacy Of Pretreatment With Lignocaine And Ketamine To Prevent Propofol Injection Pain In Patients Undergoing Surgery Under General Anaesthesia

Dr. Atlanta Talukdar, Dr. Akhilesh Chhaya, Dr. Tejash H Sharma, Dr. Priya Kishnani, Dr. Dinesh Chauhan

Abstract :

Background: Propofol is a rapidly acting intravenous anaesthetic agent, used widely for induction of general anaesthesia. However propofol has its drawback that it causes considerable pain on injection. Pretreatment using lidocaine in conjunction with venous occlusion was the most effective intervention at preventing the pain from propofol injection.Ketamine is an anaesthetic agent which has analgesic and local anaesthetic property. It was suggested that ketamine through N–methyl–d–aspartate receptors when mixed with propofol can reduce propofol injection pain. Material and Methods: This study included 50 patients of ASA (American society of anesthesiologists) I & II grade of either gender, aged 18 to 55 scheduled for various elective surgeries under general anaesthesia. Patients were divided into 2 groups (25 each). Group L will receive lignocaine 2%, 0.5mg/kg i.v and Group K will receive ketamine, 0.5mg/kg i.v. after venous occlusion applied with rubber tourniquet. The tourniquet would be released after 1 min, 3 ml bolus of 1% propofol were given over 3 seconds. Each patient were asked by an anesthesiologist to rate any sensation of pain every 5 second during the propofol injection. Verbal pain score, blood pressure and heart rate were assessed. Statistical data were analyzed by using student�s unpaired t test. Observation and Results: In this study group L, 52% of patients had no pain whereas 48% of patients had mild pain as against group K, in which 80% of patients had no pain whereas 20% of patients had mild pain (p<0.0001).It was found that patient in group L were more likely to perceive propofol induced pain than those in group K(P=0.035). It was observed that there was no significant difference in SBP, DBP, MAP or HR at any given point of time. Conclusion: The study found that pretreatment with Inj. Ketamine 0.5mg/kg under venous occlusion for 60 seconds followed by Inj Propofol for induction significantly reduced the incidence and the severity of pain during the injection of propofol when compared with the group which received of Inj. Lignocaine 2% 0.5 mg/kg under venous occlusion for 60 seconds followed by Inj. Propofol for induction