Volume : II, Issue : VIII, August - 2013

Analytical Methods for Determination of Balofloxacin in Tablets

Shreya Nayak, Sanjay Pai P. N.

Abstract :

Two new, simple, accurate and sensitive spectrophotometric methods has been developed and validated for the analysis of balofloxacin in tablet dosage formulations. The drug undergoes oxidation with a known excess of cerium (IV) sulphate in acidic medium and the residual oxidant is determined by reaction with fixed concentration of methyl orange (?max 511 nm) in first method and with indigo carmine (?max 613 nm) in the second method. The two methods have been validated separately. The Beer’s law was obeyed in the range of 0.1-2.5 μg/ml with first method and 1-7μg/ml for the second method, with good correlation coefficient of 0.9970 and 0.9980 respectively. The method was validated in terms of accuracy and precision and successfully applied to the determination of the drug in its pharmaceutical formulations. The amount of balofloxacin determined by the proposed method conformed with the label claim of the formulations.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Shreya Nayak, Sanjay Pai P.N. Analytical Methods for Determination of Balofloxacin in Tablets International Journal of Scientific Research, Vol : 2, Issue : 8 August 2013

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