ANNONA SPECIES ACTIVITY AGAINST SCHISTOSOMA MANSONI AT DIFFERENT LIFE CYCLE STAGES

Aldenir Feitosa Santos; Kelly Barbosa da Silva; Joao Gomes da Costa; Fernanda Andrade de Cesar; Monica Camelo Pessoa de Azevedo Albuquerque; Antonio Euzebio Goulart Santana

Volume : IV, Issue : VII, July - 2015

ANNONA SPECIES ACTIVITY AGAINST SCHISTOSOMA MANSONI AT DIFFERENT LIFE CYCLE STAGES

Aldenir Feitosa Santos, Kelly Barbosa Da Silva, Joao Gomes Da Costa, Fernanda Andrade De Cesar, Monica Camelo Pessoa De Azevedo Albuquerque, Antonio Euzebio Goulart Santana

Abstract :

In this study, 22 ethanol extracts derived from 6 species of Annona were subjected to biological assays in order to evaluate their schistosomicidal, miracicidal and cercaricidal activity in vitro. The plant extracts A. crassiflora (root wood),A. muricata (leaf) and A. salzmannii (leaf) showed schistosomicidal activity at concentrations of 100–10 �gmL–1. It was possible to observe that 15 extracts were active, with emphasis on A. crassiflora (stem, root wood and root bark), A. glaa (seeds), A. muricata (leaf), A. pisonis (stem), A. salzmannii (leaf) and A. squamosa (seeds and roots) for showing cercaricidal activity at < 10 gmL–1. Regarding miracicida activity 11 extracts were active and among the plant extracts evaluated, the species A. crassiflora (pulp + seeds) and A. glaa (leaf) stood out for demonstrating miracicidal activity at 1 gmL–1. These results suggest that plant extracts might be promising for the development of new schistosomicidal, cercaricidal e miracicidal agents.