Volume : VIII, Issue : IV, April - 2019

Anti–CCP antibodies and erosive arthropathy in systemic lupus erythematous

Dr Hema Murugesan, Dr Kavitha Mohanasundaram

Abstract :

Aim and Objective: 1.To describe the occurence of Erosive Arthropathy in Systemic Lupus Erythematous patients. 2. To describe the clinical significance of antiCCP antibodies in systemic lupus eythematous . Material and Methods: The study was conducted at Rajiv Gandhi Government General Hospital (2013–2014) and as extension at Stanley medical college(2015–2018). SLE patients attending the Rheumatology OPD who satisfied ACR were chosen. antiCCP antibodies was done by ELISA in 96 SLE criteria .104 RA patients who satisfied the ACR/EULAR classification criteria were also chosen for comparsion of prevalence of anti–CCP antibodies. Patients with MCTD, overlap and Sjogrens disease were excluded.. Their disease duration was less than 3years. All patients underwent high frequency musculoskeletal ultrasound. MRI hands was done in feasible patients. Results: antiCCP antibodies positivity was detected in 14.58% of SLE(n–14) and 51.92% of RA(n–54). It was significantly high in RA patients (<0.05). Erosions were noted in71.43 % of SLE which was significant with p <.0001. other skeletal manifestation observed in our study were Avascular necrosis which occurred in 6 patients(6.25%), Jaccouds arthropathy in 15 patients(15.6%) and tenosynovitis in 10 patients. Conclusions: The presence of anti–CCP has significant association with erosions in systemic lupus erythematous patients

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

ANTI-CCP ANTIBODIES AND EROSIVE ARTHROPATHY IN SYSTEMIC LUPUS ERYTHEMATOUS, Dr Hema Murugesan, Dr Kavitha Mohanasundaram INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-4 | April-2019

Number of Downloads : 122

References :