Antibiotic susceptibility pattern and emerging resistance in cases of pyodermas - A prospective study at tertiary care hospital,Nagpur.

Dr. Abhishek S. Goenka; Dr. Narendra Deogade; Dr. Ashok Gadhari

Volume : IX, Issue : IV, April - 2020

Antibiotic susceptibility pattern and emerging resistance in cases of pyodermas - A prospective study at tertiary care hospital,Nagpur.

Dr. Abhishek S. Goenka, Dr. Narendra Deogade, Dr. Ashok Gadhari

Abstract :

Introduction– Pyogenic skin infection (pyoderma) is the bacterial infection of skin and its appendages.S. aureus, Pseudomonas, E.coli, Proteus, Citrobacter, Enterobacter, Klebsiella spp. Etc are important pyogenic organisms most commonly isolated from the pyoderma cases.Rapid emergence of multidrug resistance in most of the Gram positivebacterial isolates complicates the management of pyoderma and demonstrates the need for more judicious use of antimicrobial agents. Aims and objectives– 1) To study the bacteriological profile of pyoderma casesin Nagpur district 2) To study the antibiogram of isolated organisms. Material and methods– This prospective study was conducted on 200 clinically suspected patients of pyodermas after taking informed consent. After taking proper history, samples were collected using sterile cotton swab stick and were processed according to standard microbiological guidelines for culture and antibiotic sensitivity patterns. ResultsOut of 178 culture positivity 63.5% showed the growth of S.aureus , 9.5% CONS, 4.5% S.pyogenes, 4.5% Enterococcus, 3.4% E.coli, 2.2% C. freundii , 10.1% Klebsiella spp, 4.5% Proteus spp, and 7.9% Ps.aeruginosa. S.aureus was the commonest organism isolated (63.5%), followed by Klebsiella spp (10.1%).S. aureus was 100% sensitive to Linezolid and Vancomycin followed by Netilmicin (99.1%), Amikacin (96.4%), Toamycin (87.6%), Gentamicin (86.7%).Ps. aeruginosa were most sensitive to Aztreonam (92.9%) followed by Imipenem and Pipericillin–Tazobactam (85.7%).Except for vancomycin and linezolid, resistance to all the antimicrobials tested is more among MRSA isolates than MSSA isolates.The present study indicated a relatively high rate of susceptibility among clinical isolates of MSSA to tetracycline, aminoglycosides and macrolides tested. Conclusion– As most of the cases were culture positive, pyodermas should not be ignored and should be treated. Despite various Gram negative bacterias, Staphylococcus aureusremains the most common bacteria andshould be regularly assessed for its sensitivity patterns to decide the empirical drug in a particular area.