Anticancer Chemotherapeutic agents and volatile anesthetic interaction: Comparison between sevoflurane and Desflurane

Dr Prakriti Sachan; Dr Shilpi Misra; Dr Shivani Rastogi; Dr Deepak Malviya

Volume : VIII, Issue : IX, September - 2019

Anticancer Chemotherapeutic agents and volatile anesthetic interaction: Comparison between sevoflurane and Desflurane

Dr Prakriti Sachan, Dr Shilpi Misra, Dr Shivani Rastogi, Dr Deepak Malviya

Abstract :

Context: Cancer is a leading cause of death worldwide. Chemotherapy forms an important aspect of cancer treatment. The toxicity of chemotherapy drugs and their relevance to perioperative anesthesia management relates to the specific agents used, their cumulative dosage and drug toxicity. Volatile agents have remained the mainstay of general anesthesia for decades. Volatile anesthetic agent can produce toxic metabolites and lead to varying degree of renal or hepatic dysfunction. To prepare the best perioperative management, the knowledge of acute and long–term side effects of chemotherapeutic agents is required by the anaesthesiologists. AIM: To evaluate the hepatic and renal effect of inhalational agents on oncosurgery patients receiving chemotherapeutic agents. Setting and design: prospective observational study was conducted on ASA grade 1 and 2 patients posted for oncosurgery under inhalational anesthetics. MATERIAL AND METHODS: Patients were allocated to two groups, based on chemotherapy received, then divided into subgroups according to inhalational agent used (sevoflurane versus desflurane) Group 1 – patients who have not received chemotherapy. Group Is– sevoflurane (NCS) Group Id– desflurane (NCD) Group 2 – patients who have received chemotherapy Group II s– sevoflurane (CS) Group IId – desflurane (CD) STASTICAL ANALYSIS: The statistical analysis was done using SPSS (Statistical Package for Social Sciences) Version 15.0 statistical Analysis Software. The values were represented in Number (%) and Mean�SD. RESULTS: Groups were comparable with regard to demographic data. Elevation in liver enzymes was more pronounced in the chemotherapy group as compared to non–chemotherapy group. There was no significant difference in renal function in either group at any time interval. CONCLUSION: Sevoflurane was found to have more elevate liver enzyme in comparison to desflurane though elevation in liver enzymes was for transient period. Considering the side effects of chemotherapeutic agents, vigilant monitoring of hepatic and renal function test are required in oncosurgery patients exposed to inhalational anesthetics.